Chemical tools for the elucidation of the role of PARP7 in the innate immune system Public Deposited

PARPs are a family of 17 proteins that regulate a diverse range of cellular processes through the transfer of ADP-ribose from NAD+ to amino acids on protein targets, a process known as ADP-ribosylation. Identifying the protein substrates of an individual PARP family member is essential for understanding its cellular role; however, doing so remained an impracticable task until the development of chemical genetic strategies.


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  • Rodriguez.Kelsie.2021.pdf
  • https://doi.org/10.6083/707958363
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  • 2021
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