Toll-like Receptor Four and Neutrophil Contributions to Endotoxemia- Enhanced Aminoglycoside Ototoxicity Public Deposited

Drug-Induced Ototoxicity is a widespread global problem occurring as a side effect of otherwise effective therapies for conditions such as bacterial sepsis (aminoglycosides) and cancers (platinum-based chemotherapy). It is becoming clear that having the conditions requiring these drugs itself puts the patient at increased risk for acquiring life-long hearing loss. This apparent clinical paradox places the provider in difficult position where treating the life-threatening condition will most likely result in poor hearing outcomes. Since these ototoxic therapies are both life-saving and economically viable, understanding the mechanisms of hearing loss and developing effective strategies to preserve hearing during treatment for life-threatening illness has the potential to greatly enhance the quality of life in vulnerable patient populations.

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  • 0000-0003-0707-7716
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  • doi:10.6083/M4N29WH9
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  • 2018
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  • Urdang, Z. "Toll-like Receptor Four and Neutrophil Contributions to Endotoxemia- Enhanced Aminoglycoside Ototoxicity" (2018). OHSU Digital Collections. https://doi.org/10.6083/M4N29WH9
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