Regulation of platelet function: molecular pathways and targets Public Deposited

Platelets are the first defenders of vascular integrity, responding to vascular injury in a regulated sequence of adhesion, activation, and aggregation that enables formation of a hemostatic plug. Signaling pathways within the platelet are tightly regulated to orchestrate platelet response to injury while dampening platelet activity in quiescent conditions. Dysregulation of platelet function,however, may play a central role in thrombosis and inflammatory disease. The present research defines signaling pathways that activate platelets, with an emphasis on receptors and effectors that are potential targets for novel platelet therapeutics.

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