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Abstract
Adolescence is a period of neurodevelopment, which renders the brain vulnerable to the neurotoxic effects of alcohol. Preclinical and human studies suggest that frontal and parietal cortices – regions critical for intact working memory (WM) – may be impacted by binge drinking during this time. While cross-sectional studies have shed light on differences in working memory brain activation between binge-drinking adolescents and non-using peers, few have used longitudinal data to investigate the development of working memory in the brain. The current study used functional magnetic resonance imaging (fMRI) to examine the developmental trajectories of brain response during spatial WM in 55 adolescents.