Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States (US), with about 43 million cases in 2018, many of which occur in teenagers and young adults. There are 36,500 HPV-attributable cancers annually with over 90% preventable by HPV vaccination. However, the national vaccination coverage remains below 60%. The aim of this quality improvement (QI) project was to improve HPV vaccination rates in a pediatric clinic with low HPV vaccination coverage. The project used Plan-Do-Study-Act (PDSA) methodology for improvement. It developed a patient portal (MyChart) vaccination reminder/recall system (VRRS) to send out monthly recall messages automatically to eligible patients aged 11 years and older who had MyChart. This project developed a convenient MyChart VRRS but potentially impacted by COVID-19, did not increase HPV vaccination rates.