Genomic Instability of Solid Tumors and Clinical Applications Public Deposited

Chromosomal abnormalities caused by genomic instability are a consistent feature of
cancer cells. However, the mechanisms that lead to genomic instability and its role in cancer
progression, and ultimately clinical outcome, are not well understood. Advances in whole
genome sequencing and other high-throughput molecular techniques have vastly improved our
ability to characterize cancers. Researchers have begun to measure genomic/chromosomal
instability (GI/CIN) by using multiple data types, including copy number, gene expression, and
somatic mutations. These measures of instability have been associated with various clinical
outcomes, but results have been inconsistent. Several methods for creating summary measures of
CIN have been published, but there is no consensus about the best method. Additionally, it is
unclear whether any one method is appropriate for all cancer types. Current methods also do not
take advantage of information about specific cytogenetic abnormalities that are recurrent in
specific cancer types. Given the potential clinical value of CIN as a predictor of cancer
progression or treatment response, there is a critical need to better understand how best to
summarize measures of CIN.

  • choonoo.gabrielle.2018.pdf
Publication Date
  • 2018
Document type