Evaluation of dorsal striatal functional connectivity differences across heavy and non-heavy alcohol drinking rhesus macaques with resting state functional magnetic resonance imaging Public Deposited

Resting state functional MRI (rsfMRI) is a novel imaging tool used to indirectly assess the neural activity within the brain. Literature points to a disrup-tion of cortical-subcortical circuitry in alcohol use disorders (AUD). Correlation of individual ethanol drinking averages with intrinsic functional connectivity (FC) may highlight maladaptations within these subcortical structures.The CAU and PUT are striatal structures involved in addiction-related brain circuitry. The PUT is an important structure heavily associated with habitual behaviors (chronic heavy drinking). Prior electrophysiological studies found a de-crease in inhibitory neural transmission to the PUT in HD primates after prolonged consumption. Our results showcase a selective decrease in FC of the dorsal striatum in HD monkeys within the sensorimotor network post-drinking.


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  • RuanoEspinoza.Kricia.2022.pdf
  • https://doi.org/10.6083/ff3656199
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  • 2022
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