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Abstract
Non-typhoidal Salmonella (NTS) causes an estimated 1.4 million infections annually in the U.S., yet population-level data on antimicrobial resistance are limited. Using statewide surveillance in Oregon, we analyzed culture-confirmed Salmonella cases for demographics, exposures, and outcomes. Isolates were serotyped and tested for resistance to key antibiotics; clinically important resistance (CIR) was defined as reduced susceptibility to ampicillin, ceftriaxone, ciprofloxacin, gentamicin, or trimethoprim-sulfamethoxazole. We examined resistance trends and modeled risk factors for CIR compared to pan-susceptible isolates. Findings provide insight into antimicrobial resistance patterns and associated exposures, informing public health strategies to mitigate resistant NTS infections.