The Modulatory Role of TAAR1 in Neurotoxicity of Substituted Amphetamines Public Deposited

Methamphetamine (MA) use is a global epidemic, causing mental, physical, and societal damage. Although dopamine (DA) dysregulation is the hallmark of MA-induced neurotoxicity, many underlying mechanisms remain unknown. The trace amine-associated receptor 1 (TAAR1) is activated by numerous agonists, including MA and 3,4 methylenedioxymethamphetamine (MDMA). Activation of TAAR1 inhibits DA neuronal firing and decreases rewarding effects of amphetamines, suggesting TAAR1 mitigates their harmful effects. This dissertation investigated the regulatory role of TAAR1 on transitory and sustained neurotoxic effects of amphetamines in a mouse model. Neurotoxicity was assessed through quantification of striatal biomarkers indicative of DA terminal degeneration and astrocyte activation. Thermal response to amphetamines was also recorded as hyperthermia exacerbates neurotoxicity and hypothermia can provide neuroprotection.

Creator
ORCID
  • 0000-0002-4753-7548
Degree
Department
Institution
School
Publisher
Identifier
  • nicholas.miner.2019.pdf
  • 10.6083/qf85nb81p
Keyword
Date
  • 2019
Document type
Citation
  • Miner, N. "The Modulatory Role of TAAR1 in Neurotoxicity of Substituted Amphetamines " (2019). OHSU Digital Collections. nicholas.miner.2019.pdf
In Collection:
In Administrative Set:

Items

Downloadable Content