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Abstract

Substance use disorder is a chronic, often relapsing disease that can include a loss of behavioral inhibition and compulsive drug-seeking. Acquisition of a reward seeking behavior often begins when cues are paired with rewards. These cues are thought to influence subsequent extinction (animal model of exposure-based therapy) and relapse-like behavior, both in humans and animals. My work found that acquisition and extinction of cocaine-induced conditioned place preference (CPP) were sensitive to the configuration of the apparatus and that the dorsal hippocampus (DH) regulated expression of CPP after acquisition and extinction.

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