Careful selection and optimization of esophageal cancer patients for esophagectomy is necessary and has been shown to improve outcomes. Preoperative frailty measures, both objective and subjective, may predict postoperative outcomes after minimally invasive esophagectomy (MIE) and be applied to surgical decision-making and patient selection. We hypothesize that measures of increased frailty are associated with major complications after MIE for esophageal cancer. This is a prospective cohort study of patients undergoing MIE for esophageal cancer in a US academic tertiary hospital over one year (2021). Co-authors: Conroy, Molly Johnson, Alicia Qureshi, Alia