This project aimed to develop a structured policy surrounding the therapeutic environment of esketamine to provide continuity of care and maximize therapeutic benefits while mitigating possible side effects of esketamine. A literature review for the most relevant and up-to-date evidence-based knowledge helped to develop recommendations for the following categories: environment, therapeutic techniques, anxiety, dissociation, nausea, temperature control, happiness, excitement, hypertension, and respiratory depression. CDC's Policy Analytical Framework was used to guide the development of a written policy that the organization accepted. Furniture, monitoring equipment, cranial electrotherapy stimulation devices, temperature control devices, music and meditation listening devices, and creative activities were sourced and purchased, giving special consideration to color, safety, and comfort. Given these recommendations, treatment rooms began the process of being redesigned to help support a standardized therapeutic environment in which esketamine is administered to remove inconsistencies and establish consistency for staff and patients.