The major paradox confronting tumor immunology today is how tumor cells escape cell mediated immune destruction in hosts with demonstrable tumor immunity. Unfortunately, animal models in which to study these non-specific humoral factors are unsuitable. Or unavailable. The purpose of this research project, therefore is a.) to develop a suitable animal model system to study tumor immunity and b.) to investigate the influence of non-specific humoral factors on tumor growth as a possible mechanism to account for escape of tumor cells from immune destruction.