This capstone project will evaluate and analyze user interfaces for online molecular biology databases and corresponding journal reference databases. This project will assess the available features and the usability of the web interfaces to NIH (National Institutes of Health) sponsored molecular biology databases, and journal reference databases. The project will also assess the web interfaces to Ensembl, KEGG, and EMBL databases. Evaluation will be done by interviewing scientists on their assessment of the above-mentioned databases. Furthermore, the evaluation of the web interfaces will be supported by journal article references from studies and reviews conducted by the scientific community. Finally, this project will conclude with a cross-web interface analysis to assess differences and similarities of the web interfaces and, a critical journal review to evaluate the substance of the included journal article references.