The implementation of information technology in the health care environment has grown rapidly in the last several years. Increased reliance on information systems can result in negative end-user acceptance and impact patient care when there are system issues or application downtime Enterprise monitoring is a means of preventing this negative impact on end-users and patients. This study reviewed enterprise monitoring of a laboratory information system at a multi-facility healthcare organization. This review was accomplished by gathering current monitoring parameters from the monitoring application IT staff workflow from the organization troubleshooting database and current staff training procedures. Though enterprise monitoring is effective at this organization areas to improve upon include improving alert instructions or unclear messages checking for obsolete system functionality looking for underutilized or misdirected alerts and implementing staff training documentation.