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Abstract

Single nucleotide polymorphism genotyping provides a method of genotyping ideally suited to high throughput operations. However, individual variation at SNP loci presents little information regarding genotype or phenotype on a locus-by-locus basis. Computational inference methods provided solution for haplotype determination that is low cost, highly accurate, and suited to high throughput. The Oregon National Primate Research Center (ONPRC) has begun to utilize SNP genotyping but lacks an integrated solution for uploading to the Genome Resource Informatics Program Database and for subsequent analysis of that data. This thesis describes the design and implementation of a data upload and haplotype inference system for ONPRC.

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