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Abstract
Nervous system development requires precise transcriptional regulation, with REST (RE1-silencing transcription factor) acting as a key repressor of neuronal genes in progenitor cells. Contrary to earlier reports that REST is absent in mature neurons, this study demonstrates REST expression and chromatin binding in multiple adult brain regions using custom antibodies, knockout models, and imaging. REST regulates target gene expression in a region-specific manner and shows age-dependent changes in both mouse and human brains, suggesting an unexplored role in neuronal function and potential relevance to neurodegenerative diseases such as Alzheimer’s.