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Abstract
Alcoholism is a debilitating disease, influenced by both biological (genetic) and environment factors. Unfortunately, the genetic determinants of risk remain largely unknown, hindering effective prevention and treatment of dependent individuals. The aim of my dissertation was to assess the caudolateral substantia nigra pars reticulata (clSNr) as a region through which Mpdz affects EWD, and assess the potential role of the Mpdz gene in predisposition to binge-like ethanol drinking. Further, the aim of my dissertation was to assess the effect of MUPP1 on γ-aminobutyric acid type B receptor (GABABR) mediated responses, as an important step towards identifying how this gene may influence EWD and potentially binge-like ethanol drinking.