Neonatal hyperbilirubinemia is a universal healthcare problem in pediatrics that often requires time-sensitive treatment to prevent irreversible neurologic sequelae. Although providers have guidelines for the effective management of neonatal hyperbilirubinemia there is great variation in the proper execution of these guidelines. Clinical decision support systems embedded into electronic health records have been shown to improve clinician adherence to guidelines and improve patient care This capstone project outlines how to develop such a clinical decision support system for the management of neonatal hyperbilirubinemia in the emergency department and inpatient settings. To develop the system the current guidelines and institutional clinical pathways and workflows were reviewed and then use cases Boolean logic and test cases were designed The results of this capstone project provide a blueprint for the development of an electronic decision support tool. The challenges of putting this tool into practice and next steps for extending this work are also discussed.