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Abstract
Symptom cluster research in cancer has linked reports of cognitive problems, depression, and fatigue, along with sleep disturbance, anxiety, and pain in a psychoneurologic symptom cluster, potentially with a shared underlying inflammatory cytokine mechanism. Better understanding of the levels and trajectories of attentional function, depression, and fatigue and the relationships among these variables is needed to pursue knowledge of underlying mechanisms and to develop interventions targeted at helping to manage cancer-related symptoms. The purpose of the study was to describe how levels of attentional function, fatigue, and depression change over time and whether levels and trajectories of fatigue and depression predict levels and trajectories of attentional function in women with breast cancer being treated with chemotherapy.