As women age, most outlive their spouses and rely on daughters as care partners at the end of life. In many family care dyads, relationship quality is known to be protective. Yet most of what is known of relationship quality in caregiving is taken from studies of spousal caregivers, and/or of patients with dementia. Additionally, this literature predominantly focuses on care providers rather than patients, and on factors related to burden rather than protection. Finally, it overlooks the end-of-life context, particularly dying at home with hospice, in line with patient and care partner preferences. Understanding relationship quality in mother-daughter dyads at the end of life—and how these relationships may or may not influence the hospice context—is a critical first step to meeting any unique needs this most prevalent care dyad may have.