Lysosomal abnormalities in oligodendrocytes in murine models of Krabbe Disease

Researchers have made significant progress in understanding Krabbe disease symptoms, causes, pathophysiology, epidemiology and treatments. Over the years, the psychosine hypothesis has survived and been refined, but additional molecular and cellular mechanisms have been proposed to explain Krabbe disease pathologies. However, our knowledge of the mechanisms and treatments for Krabbe disease is still limited, yet significantly more advanced than in the 20th century.