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Abstract
Heart failure (HF) is a growing syndrome characterized by burdensome symptoms and poor quality of life. Engagement in self-care behaviors is important to effectively manage symptom. Objective: 1) To gain new knowledge regarding the biologic underpinnings of HF symptoms and the associations of HF symptoms with self- care behaviors, particularly over time. 2) To enhance our understanding of how an objective marker of worsening HF and self-care behaviors influence health-related quality of life (HRQOL).