Go to main content
Formats
Format
BibTeX
MARCXML
TextMARC
MARC
DublinCore
EndNote
NLM
RefWorks
RIS
Cite
Citation

Files

Abstract

Hair cells transduce physical forces into electrical signals in nerves through a process called mechano-electrical transduction (MET), allowing auditory and vestibular perception. While the molecular identity of the pore-forming subunits of the channel remains a topic of debate, researchers have identified many proteins that are indispensable to MET. Only a select few are directly involved in gating the MET channel. In this dissertation, we used zebrafish to study two proteins involved in gating this channel, Protocadherin 15a (Pcdh15a) and Transmembrane Inner Ear (Tmie). Pcdh15a was previously confirmed to comprise the base of a rope-like structure that transfers mechanical stimulation to the channel.

Details

PDF

Statistics

from
to
Export
Download Full History