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Abstract
Coronary artery disease (CAD) involves progressive calcification of atherosclerotic plaque, measurable as coronary artery calcium (CAC) using multidetector computed tomography (MDCT). This study evaluated whether lifestyle modification influences CAC progression and whether changes in traditional CAD risk factors predict CAC outcomes. Among 22 participants with baseline and 1‑year 64‑MDCT scans, only 9.1% showed CAC reduction, while nearly 60% experienced more than 20% progression. Multivariable analyses found no significant associations between changes in LDL cholesterol, blood pressure, BMI, or functional capacity and CAC progression. Age, gender, and baseline CAC score were the strongest predictors of CAC change. Larger studies with longer follow‑up may clarify relationships between risk‑factor improvement and CAC progression.