Health disparities in maternal-child outcomes (preterm birth, low birthweight, infant mortality, and maternal mortality) are substantial, well documented, and in many cases, growing worse. Many research approaches have focused on single risk factors, yet many risk categories (e.g., minority status, socioeconomic status, violence, substance abuse, and mental health issues) overlap substantially. Further, stress and discrimination are potentially common factors to risk categories, but their role in maternal-child health disparities is not well understood. This mixed-method, participatory research study aimed to address this gap by describing the experience of pregnancy and early motherhood among a sample of diverse, primarily low-income mothers. The study focused on mothers’ experiences of stress and discrimination related to race, socioeconomic status, violence, mental health issues, and/or substance use, using an intersectional framework to understand how these factors overlapped and intersected.