Central nervous system infections, like brain abscesses and subdural or epidural empyema, in pediatric patients are life-threatening and rapid treatment is necessary to prevent significant morbidity and mortality. Late into the COVID-19 pandemic, Oregon Health & Science University (OHSU)/Doernbecher Children’s Hospital (DCH) hospitalized several pediatric patients with sinusitis and/or orbital cellulitis with intracranial infections including brain abscess and epidural or subdural empyema's. The goal of this study was to report our institutional experience with intracranial infections before and during the COVID-19 pandemic.