HIV/AIDS is a chronic disease that causes increased inflammation and decreased immune function within people living with HIV (PLWH). A majority of PLWH are women; however, very little research has focused on the unique metabolic changes that occur in women living with HIV (WLWH). While HIV was once considered fatal, current antiretroviral therapy (ART) treatments can effectively control viral loads and allow PLWH to have near-normal life expectancy. This causes WLWH to experience age-related hormonal changes known to have systemic metabolic effects, such as estrogen deficiency associated with menopause. Increased age, inflammation, and hormonal changes are all associated with similar comorbidities, leaving WLWH at higher risk for developing chronic metabolic disorders such as obesity, diabetes, and cardiovascular disease.