Acute cardiac injury with renal injury (acute cardiorenal syndrome) can induce chronic kidney disease (CKD), but mechanisms by which heart injury signals to kidney are unclear. Cardiac LIM protein (CSRP3) is a cardiomyocyte differentiation factor which is released into plasma after cardiac arrest. We hypothesized that CSRP3 induces myogenesis in the renal proximal tubule, inducing CKD.
Details
Title
Cardiac cysteine and glycine rich protein 3 (CSRP3) induces renal myogenesis leading to CKD
Creator
Funahashi, Yoshio : Oregon Health and Science University Hebert, Jessica : Oregon Health and Science University Munhall, Adam : Oregon Health and Science University Groat, Tahnee : Oregon Health and Science University Hutchens, Michael : Oregon Health and Science University
Meeting Name
Research Week, Oregon Health and Science University, 2023
