Acute cardiac injury with renal injury (acute cardiorenal syndrome) can induce chronic kidney disease (CKD), but mechanisms by which heart injury signals to kidney are unclear. Cardiac LIM protein (CSRP3) is a cardiomyocyte differentiation factor which is released into plasma after cardiac arrest. We hypothesized that CSRP3 induces myogenesis in the renal proximal tubule, inducing CKD.
