Neuroinflammation and mitochondrial dysfunction are early events in Alzheimer’s disease (AD) and contribute to neurodegeneration and cognitive impairment. The CD74-MIF (macrophage migration inhibitory factor) axis is a mediator of the neuroinflammatory response. DRhQ competitively inhibits MIF-CD74 binding and elicits beneficial effects in other neurodegenerative disease models. Here we evaluate its effects in β-amyloid (Aβ) overexpressing mice.
Details
Title
CD74 inhibitor DRhQ improves cognition and mitochondrial function and reduces neuroinflammation in 5xFAD mouse model of AB accumulation
Creator
Neff, Cody J. : Oregon Health and Science University Kolarsky, Noah Gladen : Oregon Health and Science University Hack, Wyatt : Oregon Health and Science University Brandes, Mikah : Oregon Health and Science University Mezza-Romero, Rob : Oregon Health and Science University Lockwood, Denesa : Oregon Health and Science University Quinn, Joseph : Oregon Health and Science University Vandenbark, Arthur : Oregon Health and Science University Gray, Nora : Oregon Health and Science University
Meeting Name
Research Week, Oregon Health and Science University, 2023
