Carcinoid tumors are neuroendocrine tumors which release prostaglandins and biogenic amines that can impact the cardiovascular system.1 In consequence, patients with metastatic disease can develop carcinoid syndrome characterized by flushing, tachycardia and syncope. The physiologic mechanisms that contribute to this hemodynamic instability are not well understood. Therefore, our study sought to establish a mouse model of carcinoid tumor metastasis that could be used to assess cardiovascular function.