The oral microbiome has co-evolved and coexisted in a symbiotic relationship within their own ecology and with the host. Understanding the oral ecosystem and how it promotes a balanced microbiome, is essential to effectively maintain or restore oral health. Of over 700 bacterial taxa, commensals Streptococcus and Corynebacterium are two of the most prevalent members of the oral microbiome. Surprisingly, the inter-species interactions between both commensals and the effect of such interactions on dental diseases have never been investigated. Therefore, in this study, we aim to understand the molecular mechanism(s) between different taxa interactions, in particularly, Corynebacterium durum and Streptococcus sanguinis, and the implications on oral diseases.