The field of microbiome research has grown exponentially over the past decade, marked by substantial investments in resources and recognition of its potential clinical significance. Microbiome data consist of highly dimensional and complex genetic information. Our study aimed to answer two key questions: first, does the microshades color palette significantly improve accessibility of the plots published in microbiome literature for those with color vision deficiency? And second, how can we make CVD accessible color palettes widely available to microbiome researchers creating plots for publication?