Sepsis is a life-threatening condition that arises from systemic infection and the body’s dysregulated response. It affects 1.7 million patients annually in the US and causes an estimated 350,000 adult deaths. Previous studies have identified several factors associated with worse outcomes. However, variation between studies exists partly due to variations between institutions and datasets employed. To better understand the factors driving sepsis and adverse clinical outcomes locally and how OHSU fits into a broader understanding of POA and non-POA sepsis, it is first necessary to understand the current state of sepsis at OHSU. This retrospective cohort study aims to identify factors associated with adverse outcomes in POA and non-POA sepsis.