Vascular Ehlers-Danlos syndrome (vEDS) is a heritable connective tissue disorder that predisposes to serious cardiovascular disease including aortopathy and arteriopathy. Many patients are initially diagnosed following severe complications such as aortic dissection, with delays in diagnosis associated with increased risk of morbidity and death. To facilitate early diagnosis, major and minor criteria are used to prompt further workup in patients with suspected vEDS. Early-onset varicose veins are one of the minor criteria used in diagnosis of vEDS. However, venous disease continues to be an under-described component, leading to poorly-defined incidence and management. To evaluate the current state of research on venous disease in vEDS, a review was performed by searching published literature in PubMed until November 21, 2023, and the resulting 156 publications were screened based on abstracts.