Cannabis is the most commonly used psychoactive substance in the world and is commonly used to cope with stress. Given that the endogenous endocannabinoid system influences physiological responses to stress, frequent cannabis consumption may alter stress reactivity. Indeed, frequent cannabis use is associated with elevated basal cortisol levels and a blunted cortisol response to stressful stimuli. However, how frequent cannabis use influences cardiovascular reactivity to an acute stress is unclear. We hypothesized that individuals that use cannabis would have blunted cardiovascular reactivity to an acute stress compared to individuals who do not use cannabis.