Postoperative infection (POI) following osteosarcoma resection has been shown to be associated with a potential survival benefit. A 2014 study by Behnke et al found no difference in survival, local recurrence, or metastasis between soft tissue sarcoma (STS) patients with or without POI. Our goal was to expand this study with a larger cohort and a different patient population to determine whether POIs were correlated with distant metastasis (DM), 5-year overall survival (OS), or 5-year disease specific survival (DSS) in patients with STS.