Tissue-resident memory T cells (TRM) are enriched in nonlymphoid barrier organs where they typically reside long-term without recirculating. These cells are functionally highly specialized for their local environment and have been demonstrated to provide protective tissue immunosurveillance against infection and cancer. Our data demonstrate the presence of TRM in these early tumors and points to the biomarker potential of these cells. In addition, our comprehensive transcriptomic analysis provides new insight into the evolution of the overall immune compartment in early primary melanomas.
Details
Title
Detecting and dissecting tissue resident memory T cells as an early melanoma biomarker
Creator
Yadav, Rashi : Oregon Health and Science University Clister, Terri : Oregon Health and Science University Doan, Khanh : Oregon Health and Science University Yu, Wesley : Oregon Health and Science University Kulkarni, Rajan : Oregon Health and Science University Moreau, Joshua M. : Oregon Health and Science University
Meeting Name
Research Week, Oregon Health and Science University, 2024