Alphaviruses are arthropod-transmitted RNA viruses, including the NIAID Category B priority pathogens Eastern equine encephalitis (EEEV), Venezuelan equine encephalitis (VEEV) and chikungunya (CHIKV) viruses. In November of 2023, the first chikungunya virus vaccine became FDA approved for use in individuals 18 years of age and older who are at increased risk of exposure to CHIKV, although no FDA-licensed antiviral therapeutics are available to treat alphavirus infection or disease, thus demonstrating a need in the field of public health. We identified a small molecule antiviral hit using a screen against CHIKV.
Details
Title
2-pyrimidone compound series prevents acute viremia and chronic chikungunya virus disease in a mouse model of infection
Creator
Streblow, Zachary : Oregon Health and Science University Haese, Nicole N. : Oregon Health and Science University Streblow, Zachary J. : Oregon Health and Science University Garazan, Atefeh : Southern Research Andoh, Takeshi : Oregon Health and Science University Bonin, Kiley : Oregon Health and Science University Streblow, Cassilyn E. : Oregon Health and Science University Denton, Michael : Oregon Health and Science University Medica, Samuel : Oregon Health and Science University Streblow, Gabriel J. : Oregon Health and Science University Kreklywich, Craig N. : Oregon Health and Science University Heise, Mark : University of North Carolina School of Medicine Morrison, Thomas E. : University of Colorado School of Medicine Patek, Ashish : Southern Research Streblow, Daniel N. : Oregon Health and Science University
Meeting Name
Research Week, Oregon Health and Science University, 2024
