John A. Benson Jr., M.D., reflects on his career in an interview covering his background and contributions in the field of gastroenterology. Benson served as the inaugural president of the American Board of Internal Medicine for sixteen years and was involved in teaching at the University of Nebraska Medical Center and Oregon Health & Science University (OHSU). At OHSU, he was also a member of the Center for Ethics in Health Care. His work earned him several accolades in medical education and clinical practice, and he wrote extensively on professionalism. In the interview, Benson discusses his career trajectory and provides detailed accounts of five significant mentors: Howard Lewis, M.D., George Saslow, M.D., Dan Labby, M.D., Charlie Dotter, M.D., and George Long, M.D. Additionally, he explores his interests in physician-patient communication, leadership, and physician advocacy.