Nociceptive inputs to brainstem pain-modulating neurons
De Preter, Caitlynn
2024

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Abstract

The brain regulates nociceptive processing through descending projections from the brainstem to the spinal and trigeminal dorsal horns. This is accomplished through endogenous pain-modulating circuits that can amplify or suppress pain-related signals, and normally maintain a balance between facilitation and inhibition of pain. The output of this pain-modulating system, via the rostral ventromedial medulla (RVM) has been extensively studied. This work describes direct and indirect pain transmission pathways from the trigeminal dorsal horn to the RVM.

Details

Title
Nociceptive inputs to brainstem pain-modulating neurons
Creator
De Preter, Caitlynn : Oregon Health and Science University : (0000-0002-6499-5372)
Contributor
Heinricher, Mary M. Advisor (Oregon Health and Science University)
Mao, Tianyi Chair (Oregon Health and Science University)
Butler, Matthew Committee member (Oregon Health and Science University)
David, Stephen Committee member (Oregon Health and Science University)
Ingram, Susan Committee member (University of Colorado)
Morgan, Michael Other (Washington State University)
Publisher
Oregon Health and Science University
Date
2024-12-02
Subjects
Keywords
DOI
https://doi.org/10.6083/bpxhc44090
Language
English
Related Resource
Has part: https://doi.org/10.1016/j.tins.2024.04.006
Has part: https://doi.org/10.1523/JNEUROSCI.0680-23.2023
Has part: https://doi.org/10.1016/j.ynpai.2021.100075
Related work citations

1. De Preter CC, Heinricher MM. The 'in's and out's' of descending pain modulation from the rostral ventromedial medulla. Trends Neurosci. 2024 Jun;47(6):447-460. doi: 10.1016/j.tins.2024.04.006. Epub 2024 May 14. PMID: 38749825; PMCID: PMC11168876.

2. De Preter CC, Heinricher MM. Direct and Indirect Nociceptive Input from the Trigeminal Dorsal Horn to Pain-Modulating Neurons in the Rostral Ventromedial Medulla. J Neurosci. 2023 Aug 9;43(32):5779-5791. doi: 10.1523/JNEUROSCI.0680-23.2023. Epub 2023 Jul 24. PMID: 37487738; PMCID: PMC10423049.

3. Hryciw G, De Preter CC, Wong J, Heinricher MM. Physiological properties of pain-modulating neurons in rostral ventromedial medulla in female rats, and responses to opioid administration. Neurobiol Pain. 2021 Sep 27;10:100075. doi: 10.1016/j.ynpai.2021.100075. PMID: 34660937; PMCID: PMC8503581.

Content Type
Dissertation
Degree Type
Ph.D.
Academic Program
Behavioral & Systems Neuroscience
Department
Department of Behavioral Neuroscience
School
School of Medicine
Grant Information
National Institute of Dental and Craniofacial Research
Copyright Status
Usage Statement
Record ID
44090
Record Created
2024-12-01
Record Appears in
OHSU Works > Student Work > Academic Programs > School of Medicine Programs > Behavioral & Systems Neuroscience
Organizations > Departments and Divisions > School of Medicine Basic Sciences Departments > Department of Behavioral Neuroscience
OHSU Works > Student Work > Degrees > Doctor of Philosophy (Ph.D.)
Organizations > Schools > School of Medicine
OHSU Works > Student Work > Dissertations
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