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Insight into the cellular and molecular mechanisms of melanoma-associated retinopathy

Mosavi-Hecht, Ryan
2024
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This dissertation showcases three independent studies that address various unknown aspects of a paraneoplastic syndrome called melanoma-associated retinopathy (MAR). Through the analysis of a MAR patient's disease evolution and the development and implementation of a novel bioassay, this text contributes substantially to our understanding of MAR pathology. These clinical findings may shape future MAR diagnosis and treatment, and the mechanism discoveries may guide strategies for therapeutic intervention or disease prevention.

Title
Insight into the cellular and molecular mechanisms of melanoma-associated retinopathy
Creator
Mosavi-Hecht, Ryan : Oregon Health and Science University : (0000-0001-7925-1758)
Contributor
Morgans, Catherine : Mentor : (0000-0002-7287-3447) : Oregon Health and Science University
Duvoisin, Robert : Co-Mentor : Oregon Health and Science University
Saugstad, Julie : Committee chair : (0000-0002-2996-9611) : Oregon Health and Science University
Yang, Paul : Committee member : (0000-0003-2294-0979) : Oregon Health and Science University
Heyer, Barrett : Other : Oregon Health and Science University
Rosenberg, Christopher : Collaborator : Oregon Health and Science University
White, Elizabeth : Collaborator : Oregon Health and Science University
Berry, Elizabeth : Committee member : (0000-0002-7574-6718) : Oregon Health and Science University
Shi, Qing : Collaborator : Oregon Health and Science University
Garrett, Tavita : Collaborator : (0000-0002-2585-4251) : Oregon Health and Science University
Sivyer, Benjamin : Collaborator : Oregon Health and Science University
Haley, Tammie : Collaborator : Oregon Health and Science University
Ren, Gaoying : Collaborator : Oregon Health and Science University
Carroll, James : Collaborator : (0000-0002-9264-4502) : Oregon Health and Science University
Aicher, Sue : Collaborator : (0000-0001-5310-4055) : Oregon Health and Science University
Publisher
Oregon Health and Science University
Date
2024-11-12
Subjects
Keywords
Geographical Subject
Oregon
DOI
https://doi.org/10.6083/bpxhc44106
Language
English
Related Resource
Is part of: https://doi.org/10.3389/fopht.2023.1226224
Is part of: https://doi.org/10.3791/65757
Is part of: https://doi.org/10.3389/fmed.2024.1445180
Related work citations

1. Mosavi-Hecht RM, Yang P, Heyer B, Rosenberg CR, White E, Berry EG, et al. Case report: Longitudinal evaluation and treatment of a melanoma-associated retinopathy patient. Front Med [Internet]. 2024 Sep 10 [cited 2024 Sep 12];11. Available from: https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1445180/full

2. Hecht RM, Shi Q, Garrett TR, Sivyer B, Morgans C. Split Retina as an Improved Flatmount Preparation for Studying Inner Nuclear Layer Neurons in Vertebrate Retina. J Vis Exp. 2024 Jan 16;(203):e65757.

3. Haley TL, Hecht RM, Ren G, Carroll JR, Aicher SA, Duvoisin RM, et al. Light-dependent changes in the outer plexiform layer of the mouse retina. Frontiers in Ophthalmology [Internet]. 2023 [cited 2023 Oct 10];3. Available from: https://www.frontiersin.org/articles/10.3389/fopht.2023.1226224

Content Type
Dissertation
Degree Type
Ph.D.
Academic Program
Physiology & Pharmacology (sunsetting)
Department
Department of Chemical Physiology and Biochemistry
School
School of Medicine
Grant Information
NIH
Copyright Status
In copyright - other owner
Usage Statement
Record ID
44106
Record Created
2024-12-18
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Record Appears in
Organizations > Departments and Divisions > School of Medicine Basic Sciences Departments > Department of Chemical Physiology and Biochemistry
OHSU Works > Student Work > Academic Programs > School of Medicine Programs > Physiology & Pharmacology (sunsetted)
OHSU Works > Student Work > Degrees > Doctor of Philosophy (Ph.D.)
Organizations > Schools > School of Medicine
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