Human papilloma virus (HPV) is estimated to have a lifetime cancer risk of 80%. The current HPV vaccine has a 90% prevention rate at preventing cancers when the vaccine series is completed prior to age 13. Parents of 9-and10-year-olds are the strongest positive influence in immunization initiation of adolescents. HPV education with a role-play activity increases the strength of recommendation when primary care clinic staff offer the HPV vaccine to parents of patients at age 9.