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Abstract
Binge drinking is associated with the genetic risk of developing alcohol use disorder (AUD) and is considered a strong predictor of AUD diagnosis. Excessive alcohol drinking produces lasting disruptions in inflammatory signaling in the brain and body. Chronic alcohol consumption leads to increased pro-inflammatory proteins which, over time, led to tissue damage. Chronic alcohol is associated with an increased risk of cancer and inflammation often is associated with cancer development and progression. The purpose of this thesis was to test the effects of apremilast administration on early-stage (four days) and initial (one day) binge-like drinking and nucleus accumbens (NAc) cytokine levels in iHDID-1 mice.