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Cite
The work presented herein advances our understanding of neoplastic-immune hybrid cells as drivers of cancer progression and metastasis. My dissertation studies reveal shared hybrid metastatic phenotypes across cancer types, including enhanced migration, immune evasion, and altered metabolism, and identify RUNX1 as a key regulator of hybrid cell invasive biology in colorectal cancer. Together, this work provides a foundation for understanding the molecular basis of hybrid cell heterogeneity and its role in cancer dissemination.
Title
Revealing the metastatic blueprint of neoplastic-immune hybrid cells
Creator
Anderson, Ashley : Oregon Health and Science University : (0000-0002-7522-846X)
Contributor
Wong, Melissa : Co-Mentor : Oregon Health Sciences University
Gibbs, Summer : Co-Mentor : Oregon Health and Science University
Gibbs, Summer : Co-Mentor : Oregon Health and Science University
Publisher
Oregon Health and Science University
Date
2025-09-18
Subjects
Keywords
Language
English
Related Resource
Has part: https://doi.org/10.3390/cancers14163871
Is variant of: https://doi.org/doi: 10.1002/hed.26692.
Is variant of: https://doi.org/doi: 10.1038/s41598-024-57381-8.
Is variant of: https://doi.org/doi: 10.1186/s40364-024-00609-6.
Is original form of: https://doi.org/10.3390/ cancers14194617
Is original form of: https://doi.org/10.3390/cancers15030827
Is original form of: https://doi.org/10.1002/cyto.a.24826
Is original form of: https://doi.org/doi:10.1038/s43018-023-00590-3
Is original form of: https://doi.org/10.1016/j.devcel.2025.03.014
Is variant of: https://doi.org/doi: 10.1002/hed.26692.
Is variant of: https://doi.org/doi: 10.1038/s41598-024-57381-8.
Is variant of: https://doi.org/doi: 10.1186/s40364-024-00609-6.
Is original form of: https://doi.org/10.3390/ cancers14194617
Is original form of: https://doi.org/10.3390/cancers15030827
Is original form of: https://doi.org/10.1002/cyto.a.24826
Is original form of: https://doi.org/doi:10.1038/s43018-023-00590-3
Is original form of: https://doi.org/10.1016/j.devcel.2025.03.014
Related work citations
1. Sutton TL, Patel RK, Anderson AN, Bowden SG, Whalen R, Giske NR, Wong MH. Circulating Cells with Macrophage-like Characteristics in Cancer: The Importance of Circulating Neoplastic-Immune Hybrid Cells in Cancer. Cancers. 2022; 14(16):3871. https://doi.org/10.3390/cancers14163871
2. Henn TE*, Anderson AN*, Hollett YR*, Sutton TL, Walker BS, Swain JR, Sauer DA, Clayburgh DR, Wong MH. Circulating hybrid cells predict presence of occult nodal metastases in oral cavity carcinoma. Head Neck. 2021 Jul;43(7):2193-2201. doi: 10.1002/hed.26692. Epub 2021 Apr 9. PMID: 33835633; PMCID: PMC9094139.
3. Whalen RM*, Anderson AN*, Jones JA*, Sims Z, Chang YH, Nederlof MA, Wong MH, Gibbs SL. Ultra-high content analyses of circulating and tumor associated hybrid cells reveal phenotypic heterogeneity. Sci Rep. 2024 Mar 28;14(1):7350. doi: 10.1038/s41598-024-57381-8. PMID: 38538742; PMCID: PMC10973471.
4. Anderson AN, Conley P, Klocke CD, Sengupta SK, Pang A, Farley HC, Gillingham AR, Dawson AD, Fan Y, Jones JA, Gibbs SL, Skalet AH, Wu G, Wong MH. Detection of neoplastic-immune hybrid cells with metastatic properties in uveal melanoma. Biomark Res. 2024 Jul 20;12(1):67. doi: 10.1186/s40364-024-00609-6. PMID: 39030653; PMCID: PMC11264923.
5. Parappilly, M.S.; Chin, Y.; Whalen, R.M.; Anderson, A.N.; Robinson, T.S.; Strgar, L.; Sutton, T.L.; Conley, P.; Klocke, C.; Gibbs, S.L.; et al. Circulating Neoplastic-Immune Hybrid Cells Predict Metastatic Progression in Uveal Melanoma. Cancers 2022, 14, 4617. https://doi.org/10.3390/ cancers14194617
6. McMahon, N.P.; Jones, J.A.; Anderson, A.N.; Dietz, M.S.; Wong, M.H.; Gibbs, S.L. Flexible Cyclic Immunofluorescence (cyCIF) Using Oligonucleotide Barcoded Antibodies. Cancers 2023, 15, 827. https://doi.org/10.3390/cancers15030827
7. Heussner RT, Whalen RM, Anderson A, Theison H, Baik J, Gibbs S, et al. Quantitative image analysis pipeline for detecting circulating hybrid cells in immunofluorescence images with human-level accuracy. Cytometry. 2024; 105(5): 345–355. https://doi.org/10.1002/cyto.a.24826
8. Anderson, Ashley N, and Summer L Gibbs. “Shooting for multiplexed pathology with Orion.” Nature cancer vol. 4,7 (2023): 930-932. doi:10.1038/s43018-023-00590-3
9. Smith et al., Dual states of murine Bmi1-expressing intestinal stem cells drive epithelial development utilizing non- canonical Wnt signaling, Developmental Cell (2025), https://doi.org/10.1016/j.devcel.2025.03.014
Content Type
Dissertation
Degree Type
Ph.D.
Academic Program
Biomedical Sciences
Department
Department of Cell, Developmental and Cancer Biology
School
School of Medicine
Copyright Status
Usage Statement
Record ID
44782
Record Created
2025-09-18
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Record Appears in
Organizations > Departments and Divisions > School of Medicine Basic Sciences Departments > Department of Cell, Developmental and Cancer Biology
OHSU Works > Student Work > Academic Programs > School of Medicine Programs > Biomedical Sciences
OHSU Works > Student Work > Degrees > Doctor of Philosophy (Ph.D.)
Organizations > Schools > School of Medicine
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OHSU Works > Student Work > Academic Programs > School of Medicine Programs > Biomedical Sciences
OHSU Works > Student Work > Degrees > Doctor of Philosophy (Ph.D.)
Organizations > Schools > School of Medicine
Theses and Dissertations
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