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Abstract

The work presented herein advances our understanding of neoplastic-immune hybrid cells as drivers of cancer progression and metastasis. My dissertation studies reveal shared hybrid metastatic phenotypes across cancer types, including enhanced migration, immune evasion, and altered metabolism, and identify RUNX1 as a key regulator of hybrid cell invasive biology in colorectal cancer. Together, this work provides a foundation for understanding the molecular basis of hybrid cell heterogeneity and its role in cancer dissemination.

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