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Touched with fire: how MYC drives life and oncogenesis

2025
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Abstract

MYC is an enigmatic master regulator implicated in nearly every facet of cellular biology. Throughout my PhD research and deep engagement with the literature, my singular goal has been to uncover MYC’s fundamental roles in normal cell function and to understand how these roles become corrupted during oncogenesis.

Details

Title
Touched with fire: how MYC drives life and oncogenesis
Creator
Oregon Health and Science University : (0000-0001-5901-2506)
Contributor
Advisor, Mentor, PI (Oregon Health and Science University)
Chair (Oregon Health and Science University)
Committee member (Oregon Health and Science University)
Committee member (Oregon Health and Science University)
Committee member (Oregon Health and Science University)
Committee member (Oregon Health and Science University)
Publisher
Oregon Health and Science University
Date
2025-09-19
Subjects
Keywords
Geographical Subject
Oregon--Portland
DOI
https://doi.org/10.6083/bpxhc44788
Language
English
Related Resource
Is original form of: https://doi.org/10.3389/fcell.2020.00224
Is original form of: https://doi.org/10.1101/2025.03.19.644227
Related work citations

1. Cohn GM, Liefwalker DF, Langer EM and Sears RC (2020) PIN1 Provides Dynamic Control of MYC in Response to Extrinsic Signals. Front. Cell Dev. Biol. 8:224. doi: 10.3389/fcell.2020.00224

2. MYC Serine 62 phosphorylation promotes its binding to DNA double strand breaks to facilitate repair and cell survival under genotoxic stress Gabriel M. Cohn, Colin J. Daniel, Jennifer R. Eng, Xiao-Xin Sun, Carl Pelz, Koei Chin, Alexander Smith, Charles D. Lopez, Jonathan R. Brody, Mu-shui Dai, Rosalie C. Sears bioRxiv 2025.03.19.644227; doi: https://doi.org/10.1101/2025.03.19.644227

Content Type
Dissertation
Degree Type
Ph.D.
Academic Program
Cancer Biology (sunsetting)
Department
Department of Cell, Developmental and Cancer Biology
School
School of Medicine
Grant Information
NCI
NCI
NIH
NIH
NIH
DoD
NIH
Copyright Status
Usage Statement
No License
Record ID
44788
Record Created
2025-09-19
Record Appears in
Organizations > Departments and Divisions > School of Medicine Basic Sciences Departments > Department of Cell, Developmental and Cancer Biology
OHSU Works > Student Work > Academic Programs > School of Medicine Programs > Cancer Biology (sunsetted)
OHSU Works > Student Work > Degrees > Doctor of Philosophy (Ph.D.)
Organizations > Schools > School of Medicine
Theses and Dissertations
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