Immunopathogenesis of emerging arboviral infections and their impact on maternal–fetal health
2026
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Abstract
This dissertation uses nonhuman primate models to define how emerging arboviruses disrupt placental function and threaten fetal health. Through comparative studies of Zika virus strains and evaluation of a virus-like particle vaccine, this work identifies key mechanisms underlying congenital disease and pregnancy loss. The development of a contemporary O’nyong-nyong virus model further expands these findings to support vaccine development and epidemic preparedness.
Details
Title
Immunopathogenesis of emerging arboviral infections and their impact on maternal–fetal health
Creator
Jaeger, Hannah : Oregon Health and Science University : (0000-0003-3285-2139)
Contributor
Streblow, Daniel : Academic advisor : (0000-0002-6828-2492) : Oregon Health and Science University
Estes, Jacob : Committee member : (0000-0002-9652-6394) : Oregon Health and Science University
McCarty, Owen : Committee member : Oregon Health and Science University
Carbone, Lucia : Chair : (0000-0002-2118-107X) : Oregon Health and Science University
Adams Waldorf, Kristina : Committee member : (0000-0002-6939-7224) : University of Washington
Estes, Jacob : Committee member : (0000-0002-9652-6394) : Oregon Health and Science University
McCarty, Owen : Committee member : Oregon Health and Science University
Carbone, Lucia : Chair : (0000-0002-2118-107X) : Oregon Health and Science University
Adams Waldorf, Kristina : Committee member : (0000-0002-6939-7224) : University of Washington
Publisher
Oregon Health and Science University
Date
2026-11-20
Subjects
Keywords
Geographical Subject
Language
English
Related Resource
Is identical to: https://doi.org/10.3390/v17060762
Is variant of: https://doi.org/10.1016/j.lanmic.2024.101030
Is variant of: https://doi.org/10.1101/2025.10.16.682761
Is identical to: https://doi.org/10.1101/2025.11.20.689439
Has part: https://doi.org/10.1016/j.ijid.2023.08.023
Has part: https://ictv.global/report_9th/RNApos/Flaviviridae
Has part: https://doi.org/10.1101/2025.01.06.25320089
Is variant of: https://doi.org/10.1016/j.lanmic.2024.101030
Is variant of: https://doi.org/10.1101/2025.10.16.682761
Is identical to: https://doi.org/10.1101/2025.11.20.689439
Has part: https://doi.org/10.1016/j.ijid.2023.08.023
Has part: https://ictv.global/report_9th/RNApos/Flaviviridae
Has part: https://doi.org/10.1101/2025.01.06.25320089
Related work citations
1. Jaeger, H.K.; Smith, J.L.; Parkins, C.J.; Haese, N.N.; Kreklywich, C.N.; Denton, M.; Labriola, C.S.; Axthelm, M.K.; Barber-Axthelm, A.; Chun, K.; et al. Comparative Analysis of Two Zika Virus Isolates in a Rhesus Macaque Pregnancy Model. Viruses 2025, 17, 762. https://doi.org/10.3390/v17060762
2. Li A, Coffey LL, Mohr EL, Raper J, Chahroudi A, Ausderau KK, Aliota MT, Friedrich TC, Mitzey AM, Koenig MR, Golos TG, Jaeger HK, Roberts VHJ, Lo JO, Smith JL, Hirsch AJ, Streblow DN, Newman CM, O'Connor DH, Lackritz EM, Van Rompay KKA, Adams Waldorf KM; Zika Expert Workgroup. Role of non-human primate models in accelerating research and developing countermeasures against Zika virus infection. Lancet Microbe. 2025 Jun;6(6):101030. doi: 10.1016/j.lanmic.2024.101030. Epub 2025 Feb 27. PMID: 40024258; PMCID: PMC12145256.
3. A Zika Virus-Like Particle Vaccine Mitigates Early Pregnancy Loss In Rhesus Macaques Hannah K. Jaeger, Jessica L. Smith, Caralyn S Labriola, Lydia J. Pung, Olivia L. Hagen, Michael Denton, Rahul J. D’Mello, Christopher J. Parkins, Whitney C. Weber, Samuel Medica, Craig N. Kreklywich, Victor R. DeFilippis, Stephen Bondoc, Kathleen Busman-Sahay, Jenna N. Castro, Gavin Zilverberg, Riely White, Margaret Terry, Aaron M Barber-Axthelm, Michael K. Axthelm, Jeremy Smedley, Matthew T. Aliota, Andrea M. Weiler, Thomas C. Friedrich, Jacob Estes, Terry K. Morgan, Jamie O. Lo, Victoria H.J. Roberts, Daniel N. Streblow, Alec J. Hirsch bioRxiv 2025.10.16.682761; doi: https://doi.org/10.1101/2025.10.16.682761
4. Infection Of Rhesus Macaques With O’nyong-nyong Virus UVIR-O804 Recapitulates Key Aspects of Human Clinical Disease Hannah K. Jaeger, Michael Denton, Takeshi F. Andoh, Craig N. Kreklywich, Lina Gao, Lydia J. Pung, Zachary J. Streblow, Ann McMonigal, Karina Ray, Brayden Graves, Magdalene M. Streblow, Aaron M. Barber-Axthelm, Gavin Zilverberg, Margaret Terry, Suzanne S. Fei, Glenn Hogan, David C. Schultz, Sara Cherry, Michael K. Axthelm, Caralyn S. Labriola, Mark Heise, Daniel N. Streblow bioRxiv 2025.11.20.689439; doi: https://doi.org/10.1101/2025.11.20.689439
5. Noisumdaeng P, Dangsagul W, Sangsiriwut K, Prasertsopon J, Changsom D, Yoksan S, Ajawatanawong P, Buathong R, Puthavathana P. Molecular characterization and geographical distribution of Zika virus worldwide from 1947 to 2022. Int J Infect Dis. 2023 Nov;136:5-10. doi: 10.1016/j.ijid.2023.08.023. Epub 2023 Aug 29. PMID: 37652092.
6. Simmonds, P., Becher, P., Collett, M.S., Gould, E.A., Heinz, F.X., Meyers, G., Monath, T., Pletnev, A., Rice, C.M., Stiasny, K., Thiel, H.-J., Weiner, A. and Bukh, J. Viruses ICoTo. Flaviviridae 2025 [Available from: https://ictv.global/report/chapter/flaviviridae/flaviviridae/orthoflavivirus#:~:text=More%20than%2050%25%20of%20known,Antigenicity
7. Bustos Carrillo FA, Ojeda S, Sanchez N, Plazaola M, Collado D, Miranda T, et al. A comparative analysis of dengue, chikungunya, and Zika in a pediatric cohort over 18 years. medRxiv. 2025.
Content Type
Dissertation
Degree Type
Ph.D.
Academic Program
Biomedical Engineering
Department
Vaccine and Gene Therapy Institute
School
School of Medicine
Grant Information
National Institute of Childhood Health and Development
National Institute of Health, Office of Research Infrastructure Programs
National Institute of Allergy and Infectious Disease, Flavivirus and Alphavirus ReVAMPP
National Institute of Allergy and Infectious Disease, Rapidly Emerging Antiviral Drug Development Initiative-AViDD Center
National Institute of Health, Office of Research Infrastructure Programs
National Institute of Allergy and Infectious Disease, Flavivirus and Alphavirus ReVAMPP
National Institute of Allergy and Infectious Disease, Rapidly Emerging Antiviral Drug Development Initiative-AViDD Center
Copyright Status
In copyright - joint owners
Usage Statement
Record ID
44832
Record Created
2025-12-18
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