Functional roles and regulation of the endogenous opioid peptide enkephalin in the hippocampal circuit

Warikoo, Natasha

doi:10.6083/bpxhc44876

Functional roles and regulation of the endogenous opioid peptide enkephalin in the hippocampal circuit

Warikoo, Natasha

2026

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Abstract

This dissertation characterizes the effects of endogenous opioid peptide enkephalin on excitability in the hippocampus. It also investigates the regulation of enkephalin expression in the dentate gyrus, as well as the contributions of enkephalin to circuit dysregulation in disease.

Details

Title

Functional roles and regulation of the endogenous opioid peptide enkephalin in the hippocampal circuit

Creator

Warikoo, Natasha : Oregon Health and Science University : (0000-0002-8329-7801)

Contributor

Schnell, Eric : Academic advisor : (0000-0002-5623-5015) : Portland VA Medical Center
Westbrook, Gary : Committee chair : (0000-0002-8108-5223) : Oregon Health and Science University
Williams, John : Committee member : (0000-0002-0647-6144) : Oregon Health and Science University
Ingram, Susan : Committee member : (0000-0003-1371-8532) : Oregon Health and Science University
Jackman, Skyler : Reviewer : (0000-0002-6500-3937) : Oregon Health and Science University

Publisher

Oregon Health and Science University

Date

2026-01-22

Subjects

Neurosciences
Neuropeptides
Opioid Peptides
Electrophysiology
Enkephalins

Keywords

endogenous opioid; enkephalin; synaptic physiology

DOI

https://doi.org/10.6083/bpxhc44876

Language

English